Sickle cell anaemia results from.

1. A chromosomal aberration

2. Non disjunction of autosome

3. A point mutation

4. Blood transfusion reaction

Identify the incorrect statement:

(1) In addition to recombination, mutation is another phenomeonon that leads to variation in DNA.

(2) Chromosomal aberrations are commonly observed in cancer cells.

(3) A classical example of a point mutation is sickle cell anaemia.

(4) Non ionising radiations cannot be mutations. 

Given below is the initial amino acids of the beta chain of a hemoglobin molecule. What will be true about this hemoglobin molecule ?

Sickel cell anaemia is

(1) an autosomal linked dominant trait 

(2) caused by substitution of valine by glutamic acid in the β-globin chain of haemoglobin.

(3) caused by a change in base pair of DNA

(4) characterized by elongated sickle like RBCs with a nucleus. 

Sickle cell anaemia has not been eliminated from the African population because :

(1) it is controlled by recessive genes

(b) it is not a fatal disease

(3) it provides immunity against malaria

(4) it is controlled by a dominant genes

Sickle cell anaemia is example of 

(1) sex-linked inheritance

(2) deficiency disease

(3) autosomal heritable disease

(4) infectious disease

Sickle cell anaemia is a classic example of

(1) Point mutation

(2) silent mutation

(3) Frame shift mutation

(4) non sense mutation

If a normal female has a sickle cell anaemic child what can be the probable genotype of that gene in that female?

(1) AA

(2) aa

(3) Aa

(4) both (1) and (3)

Which of the following disorder can’t be transmitted from a single diseased parent? 

(1) Sickle cell anaemia

(2) Haemophilia

(3) Colour Blindness

(4) Myotonic dystrophy

Which of the following genotypes could cause Sickle cell anaemia? 

1. Hbˢ + Hbᴬ

2. Hbᴬ+ Hbᴬ

3. Hbˢ + Hbˢ

4. Both ‘A’ and ‘C’.