Fredrick Griffith accidentally discovered transformation when attempting to develop a vaccine for pneumonia. He injected mice with samples from S-strain (virulent) and/or R-strain (nonvirulent) pneumococci bacteria (Sterptococcus pneumoniae). Which of the following results is NOT consistent with Griffith's experiments?

1. injected S-strain; mouse dies. 

2. injected R-strain; mouse lives. 

3. injected heat-killed S-strain; mouse lives. 

4. injected mixture of heat-killed S-strain and live R-strain; mouse lives. 

Which scientists first gave experimental evidence that DNA is the genetic material?

1. Avery, MacLeod , and McCarty who repeated the transformation experiments of Griffith, and chemically characterized the transforming principle.

2. Garrod, who postulated that Alcaptonuria, or black urine disease, was due to a defective enzyme.

3. Beadle and Tatum, who used a mutational and biochemical analysis of the bread mold Neurospora to extablish a direct link between genes and enzymes. 

4. Meselson and Stahl who showed that DNA is replicated semiconservatively.

The function of the rho protein is 

1. to help terminate translation

2. to help RNA polymerase bind to the DNA

3. to help RNA polymerase find a promoter

4. to help terminate transcription

Genetic information in a DNA molecule is coded in the:

1. Sequence of nucleotides

2. Base pairings 

3. Proportion of each base present

4. The turning pattern of the helix

In DNA replication, the Okazaki fragments on the lagging strand are joined together by:

1. DNA ligase

2. DNA polymerase

3. Primase

4. Helicase 

The enzyme that catalyzes the peptide bonding in prokaryotes is located in the:

1. Leader region of the mRNA

2. Central part of tRNA

3. Smaller subunit of the ribosome

4. Larger subunit of the ribosome

In general, bacterial genes are regulated at the time of:

1. Transcription

2. Post transcription

3. Translation

4. Post translation  

The insertion or deletion of a base pair into the genetic code will cause a frame shift mutation unless the number of base pairs inserted or deleted is:

(1) One

(2) Two

(3) three

(4) Ten

Consider the following statements:

I. The largest known human gene is dystrophin at 2.4 million bases

II. Repeated sequences make up very large portion of the human genome

III. There are about 2.4 million locations where single base DNA differences occur in humans

Which of the above statements are true?

1. I and II only

2. I and III only

3. II and III only

4. I, II and III

Consider the following statements:

I. RNA is the genetic material of the QB bacteriophage

II. DNA chemically is less reactive and more stable than RNA

III. Viruses having RNA genome and having shorter life span mutate & evolve slowly.

Which of the above statements are true?

1. I and II only

2. I and III only

3. II and III only

4. I, II and III